- f6v parentOP mentions "six minutes" as a DB metric. But the thing is that DB doesn't care about trains being late. It's absolutely normal to have an hour delay in Germany. You can be considered lucky if it's under an hour. What will usually happen is that you spend half a day in some village waiting for your connection and travel the rest of the way standing in the doorway with your bags.
- There're certain kinds of rewards to encourage traveling by rail in Europe. For example, a training course I attended refunded part of your travel expenses if you took a long-distance train. And there're people who believe in not flying for the sake of the planet.
But at this point, I'm convinced you should avoid any train in and around Germany. This includes Denmark as well. Just take a plane, but don't have a layover in Germany. The same could probably be said about France. My first train from Paris to Nancy stopped for about 2hrs in the middle of nowhere. As the machinist said: "The train is tired."
Other countries like Italy or Spain seem to actually have well-functioning rail though.
- First issue is that tumors don't necessarily have to be highly immunogenic, e.g. there're tumors that don't present many neoantigens on the surface. This means immune cells can't easily recognize them. Second issue is that tumor microenvironment evolves to be immunosuppressive. There're many different signals that regulate immune cells activation and simply having antigen-specific cells isn't enough. But as someone said in a sister thread, what you're describing is a basis for multiple clinical trials that combine antigen release with immune activation.
- I don't download any apps anymore, so not very informed on the state of alternative app stores in EU. I decided to Google where I can find those. One of the first links is leading to MacPaw's website. It's a company with questionable ethics and business practices that tries to sell you "antivirus" and "decluttering" app. So I'll pass.
But are there any real 3rd-party AppStores for iOS now? Something that's used by more than just a couple of people? Or is EU just trying to milk rich USA tech giants (I think I know the answer).
- > fixing the enzyme that fixes the wrong copy paste mechanism
The DNA fidelity issues contribute to only some cancers. Many are caused by mutations due to environmental damage and some are caused by viruses. The point is, there's a huge variety of reasons for developing cancer. So you cover more cases by developing treatments that are more "universal".
- It's not a question whether they are or not worth something. It's just that it's a much more meaningful differentiator when there's an overabundance of talent. CVs are going to be filtered based on something. And people with no degree are going to have a much more difficult time getting through the automated screening. That will come as a surprise to people who were promised they'll get a job by paying $1000 for a "nano-degree".
- > With all possible social changes like the article suggests this focus could change too.
I have an anecdote from Denmark. It’s a rich country with one of the best work-life balance in the world. Socialized healthcare and social safety net.
I noticed that during the election, they put the ads with just the candidate’s face and party name. It’s like they didn’t even have a message. I asked why. The locals told me nobody cares because “they’re all the same anyway”.
Two things could be happening: either all the candidates are really the same. Or people choose to focus on doing the things they like with their free time and resources. My feeling tells me it’s the second.
- One likely explanation is that both cannabis and alcohol users abuse substances due to an underlying process that leads to dementia. There might be something that makes you a heavy user AND prone to dementia. But, of course, we can’t say that alcohol or weed are direct causes of the disease.
- > Remember the "leaks" from Google about an engineer trying to get the word out that they had created a sentient intelligence?
No, first time I hear about it. I guess the secret to happiness is not following leaks. I had very low expectations before trying LLMs and I’m extremely impressed now.