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SilverElfin parent
> The ties are so strong that in 2023 the American Heart Association grouped the conditions under one name: cardio-kidney-metabolic syndrome (CKM), with “metabolic syndrome” referring to diabetes and obesity.

Seems like this is mostly an extension of the previously existing label of metabolic syndrome, now including kidney. Ozempic is mentioned and I take that to mean obesity is the cause. But are some of these ailments like diabetes reversible?

liveoneggs
I think it's saying that diabetes (T2 is reliably reversible) causes damage to the heart and kidney but sometimes the connection isn't made and they treat the kidney/heart symptoms without addressing the cause (T2D).
SilverElfin OP
Interesting I didn’t realize T2 is reversible. How do people do that - some kind of drug? Or just weight loss?
liveoneggs
Here's a protocol from a small study where 90+% reversed their T2D. https://link.springer.com/article/10.1186/s12916-025-04072-4

tl;dr it's everything you expect - home-cooked healthy meals, avoid sugary stuff, moderate exercise five days per week, etc

cestith
You skipped over the part where they were also still taking the standard hypoglycemic agents - in other words, medications to manage blood glucose. The study also tracked people who were both obese and newly diagnosed as diabetic. It says so in the conclusion.

Also, remember not everyone with T2 is obese, not everyone obese has T2D, and obesity doesn’t mean a little overweight. These are people with a BMI of 30 or higher. Other, lesser-used definitions from the past included a certain percentage of body weight consisting of fat. There are many people with Type 2 who are normal weight or overweight.

liveoneggs
Yes, and? What point are you trying to make?

> T2D remission is defined as glycated hemoglobin (HbA1c) < 6.5% after discontinuation of hypoglycemic drugs for at least 3 months

> In the intensive treatment group, 78.57% patients in the prediabetes subgroup returned to normoglycemia and the diabetes remission rate was 75% in the diabetes subgroup at 12 months

75% of T2D people in this study were able to get cured and stop medications. It's a good outcome.

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