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Depression is likely to have many possible underlying causes.

It’s a description of a persistent set of symptoms not necessarily any specific biological process.


>Depression is likely to have many possible underlying causes

including adaptive evolutionary procreative success

Correct.

and one of the leading causes is what I described.

You really have to unpack "detox inefficiency" because even a google search comes back with nothing.
When your normal lymphatic processes (and glymphatic processes) are slowed, or near-halted.
Can you link any evidence supporting this claim?
Beyond the links in other comments?
Is there a known correlation between lymphedema and depression?
Calling it lymphatic impairment would be more straightforward.
Lymphatic inefficiency, maybe.

Impairment sounds too permanent, when this is often an intermittent, “on average” sort of issue - not a complete freeze.

It might be worth using those words rather than detox inefficiency because the latter conjures thoughts of woo peddlers.
Yes,

it turns out toxins (environmental, die-off and waste of cells from infection, dietary, lifestyle) are important to everyone,

not just vegans in Sandler movies.

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