You can do it with various mise commands, but the simplest way is to use a mise.toml that looks something like this

  [tools]
  python = latest
  uv = latest
  "pipx:yt-dlp" = latest

  [settings]

  [settings.pipx]
  uvx = true

  [settings.python]
  uv_venv_auto = true

These are all features of the [pipx backend] for mise, and the docs discuss what to do in the case of things like python updates, etc. The advantage of doing it this way, particularly for a global mise config, is that you treat these python tools as basically any other mise tool, so their versioning is easy to control.

I know mise isn't really a package manager. But with its support for things like this, be it for python, ruby, npm, or cargo, as well as more universal support from things like Ubi and the upcoming github backends, its rapidly becoming my favorite package manager. I've a number of projects that use particularly useful node based tools, like markdown-lint or prettier, that aren't JS based in any way, shape, or form. Having to carry around a package.json felt weird, and with the way mise handles all of it, now I don't have to

[pipx backend]: https://mise.jdx.dev/dev-tools/backends/pipx.html

They may be referring to uvx: https://docs.astral.sh/uv/guides/tools/

Or it could be something else, not sure.

In mise.toml I have:

``` [tools] python = "3.12.11" ruff = "latest" ```

I get ruff installed and anything else needed without any fuss.

`uv tool install` I believe