- > They paid a total of 2 people $50,000 (edit: in 2016 dollars). That doesn't seem like enough to entirely shape worldwide discourse around nutrition and sugar.
You would be astonished at how little it takes to bribe, I mean donate, to a politician for example. For as little as $10-20k USD you can get a literal seat at a table with a sitting senator or congresscritter for several hours at a "charity" dinner, with results as expected.
- You are absolutely bonkers. This post and the rationale behind it are beyond insane.
We do not understand these ecosystems beyond their extreme fragility and low entropy conditions. This is an incredibly destructive and expensive manner of resource extraction that destroys the seabed. Why would anyone sane ever support this beyond, I don't know, someone who also thinks that clearcutting the amazon is a good idea? What kind of vested interest do you have in this blighted technology?
- Keytruda, pembrolizumab, (what he probably received) can only do so much. If it was in his GI tract it was also elsewhere in multiple places. The PD-L1 drugs at this point have more than 400k patients treated, with decent efficacy. I'm sorry for your loss. If his melanoma had metastasized to his GI tract it was too late for anything except palliative care.
This drug has been used in a huge number of patients for more than 11 years; the next gen of drugs is currently being used. I'm sorry for my curt style of writing, but - people like your father have helped pave the way for that next generation of drugs by constraining clinical trial designs.
- Sorry, as someone in this field, this is bullshit. It is in mice.
Several things trigger my bullshit meter. Quote:
"This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"
PD-L1 monoclonal antibodies are only effective against cancers that are, you guessed it, PD-L1 positive. At high percentages, ranging from 1 to 50%. Are these authors even familiar with the state of the art when it comes to cancer medications? Mouse tumors do not equate to people tumors. Many tumor types are not PD-l1 positive.
Doxy is an ancient SOC chemo.
This is a nothing burger.
Give me phase II/III clinical trials, and then let me know what their PFS/OS was after 5 years. and what the medians were at 3- and 5-years. Also, ORR and CR and needed.
CAR-T is ahead of the game, and will be the ultimate winner here as it grows to scale.
- I feel like many of the comments are focused on the trees and not on the forest. The new head of Facebook AI is 28 years old? That's not OK, that's too young. Too inexperienced and not worldwise enough by a long shot. No shit they're having problems. Can you imagine being a facebook lifer, or one of the LLM pros they've bribed/hired over to the company, to be bossed around by someone with very little life experience? No shit it isn't going well.
- The only benefit as I perceive it re: orbital data center hardware is regulatory avoidance. Think...DDOS machines that can't be shut off; or financial hosting services for unsavory individuals. However, it's very expensive by all metrics (including those talked about in the article), and frankly, these satellites are sitting ducks for the hunter killer satellites the various space powers have, if they actually wanted to do something about these hypothtical data centers and the problems they would cause.
- https://www.tsunami.gov/?p=PHEB/2025/12/08/25342050/2/WEPA40
Shouldn't be too bad; USGS forecasts up to 1 meter tsunami.
- So, I'm going to chip in with a different perspective from that of some other commentators on here. The overwhelming majority of computers in the entire world, used by our entire species, have windows as their OS.
While I applaud the use of alternatives to windows and it's apps, universities teach it because it is what their graduates will use in the real world. Governments use it because while it has it's flaws, it mostly works and is a universal standard. It's the toyota of operating systems. The parts and manpower to repair it and use it are available everywhere, and it's cheap and reliable.
- There have been several proposals. This paper proposes a feasable mechanism[1]:
-"a SBH could be artificially created by firing a huge number of gamma rays from a spherically converging laser. The idea is to pack so much energy into such a small space that a BH will form."
- My response to the money aspect of this it's just like any other business: money needs to be invested, and then a return will be realized. Resource extraction (i.e, asteroid mining) is one obvious example.
The human compatibility issues with microgravity are well known, as is the solution, which has even been proposed by NASA: centripetal force to create 1G for the astronauts.
As far the the radiation goes, we do indeed know exactly what kinds of radiation they would encounter. And the easiest way to shield humans from it in space is lots of water, or metal. We know this from extensive real work done on earth re: nuclear power plants.
The real issue is money, not technical feasibility. Once the dough rolls in from asteroid mining, it bootstraps the financing issue and pays for itself many times over.
- It wasn't intended for a communications relay, but it was intended to have 2-way communication. I went down a rabbit hole reading ArXiv papers about it. Despite their tiny size, the probes could phone home with a smaller laser - according to the papers I read, spinning the photons a certain way would differentiate them from other photons, and we apparently have the equipment to detect and pick up those photons. The point of the communication would be for them to send back data and close-up images of the Alpha C system. Likewise, they could receive commands from earth by having dozens of probes effectively act as an interferometry array.
- Not possible according to the laws of physics. The closest you can get is a solar sail, but that's not "propellant-less" - photons are the propellant.
If a company thinks they've broken one of the most fundamental laws of physics (momentum transfer), they need to provide some serious evidence, and publish in full so their results can be replicated. A press release on an obscure website isn't how you do it.
- You guys have it all wrong. There was only one candidate for the dem party, Here's the list:
1) Cuomo. Sexpest who has been accused by many women of some pretty shitty stuff. Also a member of a multi-generational dynasty, which is not good.
2) Mayor Adams. Federally indicted by the Feds. They have a 99% conviction rate. Not because they're corrupt, but because they only go after people who have dome some really egregious, illegal shit.
3) Mamdani. Millennial candidate. No dirt. Other that some stupid stuff he said while he was young, his policies are relatively common sense and middle of the road, and are aimed at leveling the playing field.
Gee, who should I choose? [[said all of NYC today]]
- To avoid mass casualties at the end of the runway - on the road, or the buildings that the runway points to. Check the layout on google maps.
More specifically, V1 is the max speed at which you're about to take off, but you can still abort from. They hit that max speed and realized there was a major problem that hypothetically, they could have slowed down from, but realistically was not possible. They had no choice.
- Unless you have a berm several dozen meters high with a 100 meter base, you ain't stopping something like this from a physics standpoint unfortunately.
Many airports have this problem. The recent korean air disaster which echos this is another example. BTW, this is why most airports, if possible, point out to sea...
Anything he says has no validity and should be given no credence by any sane person.