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notamy
Joined 5,491 karma
Computers are bad.

Contact:

echo "H4sIAAAAAAAAAx2OwXKCMBRF934NoE7rkmQaSARnHpAEsqsvY+gI2oWmkK9vdHvPPXOv0af7ec1vbbIo+3No5DRVUjIyzHuNmSDIWIod7ODrUat+8FIJ06WMgJr6ulP1WTdP2DYLJBDaLrnx8s9hpq6cphOnNlRJ7vti58VKPnk5jjjbEJmI7OPSohtmFr5p/hjiB/P+QmIeu4UYMZPZKTJDX+5vsAW4SsN7w5bciXR5iugBRXehJBj94tKJbe2Bgq9WPG7+AdivT2PhAAAA" | base64 -d | gzip -d | base64 -d | sh

  1. notamy parent
    https://en.wikipedia.org/wiki/Quantum_biology

    > Mitochondria have been demonstrated to utilize quantum tunneling in their function as the powerhouse of eukaryotic cells.

  6. notamy parent
    The title seems to have a few words missing. Original title:

    > Parsing millions of URLs per second

  8. notamy parent
    > For the more Java proficient, can someone explain why it may have provided this code:

    To me that reads like it was trying to accomplish something like

        int[] current;
    while((current = queue.pop()) != null) {
  10. notamy parent
    It’s been shown that sesquiterpenes released by plants can induce cloud formation: https://www.science.org/doi/10.1126/sciadv.adi5297

    I now wonder if they use the sound to communicate with other plants to try to get clouds to form faster

  15. notamy parent
    > Subligual methylcobalamin works just as well as the shots

    It does not. The cobalamin molecules are quite large and don’t penetrate the sublingual mucosa very well. On top of that, the proteins in saliva that bind to B12s will cause any bound B12 to not absorb sublingually, instead having to wait to make it through the digestive system for intestinal uptake.

    Sublingual is still certainly a better option than oral pills, but the injections are preferable in severe cases for a reason.

  16. notamy parent
    > Megadosing it can harm sleep and severely increase blood pressure and heart rate

    https://www.researchgate.net/profile/Osama-Arafat/publicatio...

    > METHYLCOBALAMIN HAS AN EFFECT ON HYPOTHALAMIC–HYPOPHYSEAL– ADRENAL AXIS

    In rats, but may apply to humans too.

  17. notamy parent
    > I suspect that copper is the issue with me.

    Prolonged copper deficiency can cause irreversible neuropathies and CNS damage. You should try to get tested for it if you can.

  18. notamy parent
    > Apparently this form of B9 absorbs better if it’s combined with the methylated form of B12 (methylcobalamin)

    B9 and B12 are interdependent. When the body uptakes cobalamins, the ligands are pulled off and replaced with ligands sourced from other processes. IIRC in the case of methylcobalamin, the methyl group is pulled off and replaced with a methyl group that’s moved over from methylfolate via a riboflavin-dependent reaction. Been a hot minute since I looked into this so I may have some details incorrect.

  19. notamy parent
    > The paradoxical B12 deficiency might have a relation with the inactive form being supplemented.

    Yup, not everyone can convert cyanocobalamin or hydroxocobalamin to adenosyl-/methylcobalamin. Especially in severe cases, anecdotally I’ve seen people not make progress with the standard cyanocobalamin injections, but then make huge progress with methylcobalamin injections. Unfortunately, methylcobalamin is often not preferred in injectable form due to very quick degradation into hydroxocobalamin upon exposure to light.

  20. notamy parent
    It may help, but it will also throw off lab tests while you’re taking it and for a time after. Also, B12 absorption depends strongly on good gut health (ex. no SIBO[1], low gastric acid, pernicious anaemia, etc.), as well as on other medications (ex. metformin[2]) not interfering with absorption.

    [1] https://en.wikipedia.org/wiki/Small_intestinal_bacterial_ove...

    [2] https://en.wikipedia.org/wiki/Metformin CTRL-F "B12"

  21. notamy parent
    > Vitamin B12 deficiency can cause PGH through unknown mechanism. About 55% of patients with pernicious anemia had graying before 50 years as compared to 30% in the control group.[32]

    /soapbox

    Get your B12 tested (before taking supplements!).

    B12 deficiency is known to present in many ways, and also to be often overlooked in clinical settings[1]. It’s known that not everyone presents with the anaemia from it[2], which is often why it’s skipped as a diagnostic option. Additionally, long-term/severe deficiency can present with symptoms almost identical to multiple sclerosis[3]. Deficiency of other B vitamins, such as B2, can cause a functional B12 deficiency as well[4]. It’s also known that supplementation will falsely elevate levels even in the presence of a deficiency.

    /unsoapbox

    [1] https://www.mcpiqojournal.org/article/S2542-4548(19)30033-5/...

    [2] https://www.bmj.com/content/383/bmj-2022-071725

    [3] https://researchonline.nd.edu.au/cgi/viewcontent.cgi?article...

    [4] https://www.iomcworld.org/articles/paradoxical-vitamin-b12-d...

  23. notamy parent
    Fingers crossed UT2004 will end up in the Archive eventually. I still boot it up to play occasionally because nothing else has scratched the arena shooter itch that well.

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