2
points
colingauvin
Joined 312 karma
Structural biologist
- >Government actions that restrict the ability to privately own or make use of computational resources for lawful purposes, which infringes on citizens' fundamental rights to property and free expression, must be limited to those demonstrably necessary and narrowly tailored to fulfill a compelling government interest in public health or safety.
....what does this say about DRM enforcement?
- I work in drug discovery (like for real, I have a DC under my belt, not hypothetical AI protein generation blah blah) and had the opposite experience reading it. We understand so little about most drugs. Dialing out selectivity for a closely related protein was one of the most fun and eye opening experiences of my career.
Of course we've thought of all these things. But it's typically fragmented, and oftentimes out of scope. One of the hardest parts of any R&D project is honestly just doing a literature search to the point of exhaustion.
- On the technical side, yes. The biggest new developments I can quickly think of are:
1) Cold field emission guns. The big challenge of an electron source is producing a coherent beam - that is a beam that comes off the tip one electron at a time, at the same location, the same angle, and with the same energy. The cooler the tip runs, the more coherent it tends to be. This has made a big difference and is just now widely commercially available.
2) Narrow pole-piece gap. The sample on most TEMs sits sandwiched between two objective lenses that operate in tandem - these are typically called twin objectives. The upper one ensures the beam is parallel, which primarily results in uniform defocus (or focus if one so desires) across the image. The lower one is responsible for image formation and initial magnification (actually, all of your resolution essentially). The gap between them is responsible for your primary aberrations: spherical and chromatic. Reducing this gap reduces the total aberrations in the image.
I will side bar that the physics of a microscope are not really holding it back from what I'm doing - generating structures of biomolecules. Really, I'm more limited by the camera technology than anything, because the cameras simply aren't performant enough to dose the images to the level I'd like, to collect as many images as possible in as short a time as possible. Fundamentally, I tend to be limited by number of observations.
For the really cutting edge stuff...check out ptychography:
https://en.wikipedia.org/wiki/Ptychography
>How does one become a microscopist as a profession? It seems like a specialized field with a narrow entry point and a lot of hoops.
There are basically two routes for TEM - material science, or biochemistry. The way to become a microscopist for me was to show up at a University that had a grant for a microscope, but no one to operate it. :)
In general, universities operate TEM cores, frequently called bioimaging or something. (Structural biology if it's newer although that's just one application among many). Frequently there are positions for all education levels - bachelor's through PhD, depending on what one wants to do. Training is a mix of hands on (interfacing with complicated systems) and theoretical (physics and image formation). Typically the operators aren't the most theoretical, but have a lot of very niche practical knowledge you only get from being around broken microscopes.
- I am a cryo-electron microscopist (TEM), will keep an eye on this thread in case there's any specific questions.
(Also have done Xray crystallography)
- All available evidence suggests this does not work at population scale.
- If you're worried about the possible, unknown side effects of GLP1s, check out the inevitable, well-known side effects of being morbidly overweight.
- I went to a friend's outdoor wedding in July where water was $2.50/bottle.
- A lot of replies that are mostly true, or somewhat true, or simply missing the real reasons.
There are two factors here:
1) Vaccine-derived immunity is a function of the individual's immune response, which in general, weakens significantly with age. It is not unrealistic for a vaccine to simply fail to elicit any response in someone old enough.
2) It is very, very difficult to recruit folks without HPV that are over 40 for a clinical trial. Most people of that age, who were never immunized, most likely have had it. This significantly convolutes the signal.
3) This is all especially confounded once something becomes "standard of care". Every year there are fewer and fewer people age 40+ with HPV.
For these reasons, the vaccine is currently officially ??? in people over 40. Most doctors will prescribe it anyways if you ask. It may or may not infer immunity. It almost certainly will not harm you.
- It started when I had my first kid and he wouldn't sleep and I would lay there awake all night just thinking of all the stressors in my life. I'd use the phone to distract myself. Then that gradually just turned into a crutch for all stress. That was pretty hard to stop.
I've tried a number of different things but nothing stuck. I've had this phone for a few months now and it has really done the trick.
- It's doable in the web browser. Clicking small links is annoying and makes it much more self limiting after a number of mis-clicks.
- I can confirm that this phone is perfect for it. Everything is there and usable if you truly need it, but I cannot wait to put the phone back in my pocket because of unpleasant it is to use.
- I picked up one of these and have been having a number of issues, but have somehow managed to stick with it and my life is much improved as a result. Device usage has been much, much more intentional. I wouldn't say I'm cured of my scrolling addiction, but the time I spend scrolling has been relegated to just the latest hours of the night, and even then, significantly less.
The trick about this phone is that because it is full fat Android, everything is possible. But because it is low refresh rate black and white screen with a physical keyboard, everything is also a pain in the ass. Rather than hear a chat message notification and immediately get the urge to pull out my phone and engage, I actually now get slightly annoyed because typing out a proper response with proper grammar is going to be a pain in the ass.
The company is pretty lousy and doesn't communicate well. They have missed every single deadline they've ever set for themselves. The software is glitchy but usable (I have all the same issues mentioned in the article with the autocorrect, refresh settings, fingerprint, etc). All those things are fixable and hopefully do.
The phone itself is very weak hardware and the screen protector and case still haven't shipped. I had my phone in my back pocket and it did not survive that, I got two cracks along the edge and a slight bend. Still works though, but I have switched it to my front pocket.
Android Auto works great in both my vehicles, so maps/navigation are not an issue. Bitwarden works. Duo auth works. Banking apps work. Roon works. Podcasts work. Things that I need, that other dumb phones can't provide.
But the critical thing is, I am trying to avoid using the phone because it is just a pain in the ass to do things on. For this, honestly, I'd pay 10x the list price because it has given me so much of my life back. I actually had a mini crisis when I realized I was bored, with nothing to do in the evenings after work, because I had so much time back. (Don't worry, channeling that time into productive hobbies now).
I would highly highly highly recommend this if you want to spend less time on your phone but need certain functions a smartphone provides.
- >I'm not a scientist, but if you were to tell me "this trial shows that substance X is not harmful", I would think ideally it would give substance X to one group and a placebo to the other group. If not possible, it would look after the fact to see group A that received substance X compared to group B that didn't, large enough sample so it would be relatively controlled for extraneous variables. Seems like you would def want to compare the two groups, so what did this study actually do?
You cannot give a placebo vaccine once is it standard of care. No IRB is going to approve a placebo control group for a study (nor should they) on a vaccine that is already SoC. This is why we let actual scientists and doctors design the experiments, and not random HN readers. It would be incredibly unethical to give a placebo vaccine for tetanus. Think about what you are suggesting here. You are suggesting that children potentially die of entirely avoidable tetanus, for the sake of running an experiment. At the bare minimum, that is medical malpractice. I won't get into what it is at the other end of the spectrum, beyond this:
- They are making a b&w one as well.
- This is so out of touch it is almost comical.
- For the uninitiated:
https://en.wikipedia.org/wiki/Buffalo_buffalo_Buffalo_buffal...
- I was surprised to find that there is an Italian Mediterranean buffalo species/breed [1] that is thought to be descended from an altogether distinct lineage that went extinct around the last ice age [2].
[1] https://en.wikipedia.org/wiki/Italian_Mediterranean_buffalo
- Tesla was found partially liable for this crash. The reason they were liable was they sold something claiming (practically speaking) that it could do something. The customer believed that claim. It failed to do that thing and killed people.
So the question then is - how much did Tesla benefit from claiming they could do this thing? That seems like a reasonable starting point for damages.
This is interesting because of "supposed" cardiovascular effects of the vaccine that many folks were worried about. Even more confounding is the gender differences. You'd think skewing women would skew away from cardiovascular issues.
An alternate interpretation is that the at risk cardio unvaccinated died of COVID for some reason.