- PilottwaveCreatine might not be without risks. Search for creatine withrawal symptoms. Some people are wrecked for months when they quit the supplement. I tried one cycle of 4 weeks and quit cold turkey and had a crash/depressive episode unlike i ever experienced before for about 7 days. I did like the benefits, it provided me resitance to mental fatigue. Roughly i'd say i experienced a "+30% boost", significant!
- I was just recently talking to my fellow ADHD friends on the benefits that i felt when i started vaping this summer. It was like i was medicating away my ADHD. I turned to AI to investigate further, its response seemed to underwrite this observation
Gemini output: Research is exploring nicotinic acetylcholine receptor (nAChR) agonists as a potential non-stimulant treatment for ADHD, sidestepping the issues of pure nicotine's high addiction liability.
The mechanism focuses on boosting dopamine (DA) and acetylcholine (ACh) release in brain areas governing attention and executive function, primarily by targeting the alpha4beta2 and alpha7 nAChR subtypes.
The goal is highly selective compounds that target the cognitive benefits (linked to alpha4beta2) while avoiding undesirable side effects and addiction pathways.
Selective alpha4beta2 Agonists (e.g., ABT-418, ABT-894/Sofinicline): These were developed to strongly activate the receptor most associated with DA release. Pilot and Phase II studies showed a signal of efficacy in adults with ADHD, with effect sizes similar to non-stimulant medications like atomoxetine.
Varenicline (Chantix/Champix): This is a partial alpha4beta2 agonist, FDA-approved for smoking cessation. Smaller trials suggested improvements in ADHD symptoms, but large-scale development for ADHD has been limited or terminated, and it is not approved for this indication.
Bupropion (Wellbutrin/Zyban): An established non-stimulant ADHD treatment (NDRI) and smoking cessation aid. While its main action is norepinephrine-dopamine reuptake inhibition, it also acts as a nicotinic receptor antagonist (blocking it), which is believed to help reduce nicotine craving. It is an approved non-stimulant option for ADHD.
- It is so useful, for me a must have on every phone. on Android the app aodNotify is what I've been using to recreate it.
- We are closer then ever before. Yes the tech is in its infancy, it's like buying a computer in the 80's. Some dream of the possibilities and chase them, others ridicule all this effort pouring in. History currently is on the side of technical innovation speeding up. humans are getting further faster and leveraging new tech to do so. I'm more concerned if our society handles this rate of change well, and what models in the future, that have the intellectual power of every human that has ever lived combined, will do as soon as someone sets them loose in full self agency mode. I hope it's everything the best of us aspire to be. I hope that models value truth above all else, I suspect truth and usefull training data are closely related. so yes, claims made are well within the realm of outcomes.
- I just want some basic functions that were present in all previous Windows versions. Classic start bar in a vertical position on the second screen only. hear my prayers Microsoft
- Very nice I have subscribed to test it out for a couple of weeks.
I would love a simple mobile app, it's just easy to tap your news app on a phone, ideally with a way to customize the notification timing. I have certain moments each day when I want to consume this type of content (breakfast, lunch break)
A small community driven comment section with Karma system would also be nice. I like to discuss news and it enables knowledgeable people to add some additional insights. See the dutch tech news site for inspiration. they explain their karma system here: https://tweakers.net/info/faq/karma/#tab:1-2
- Calling cutting edge-models consumer facing models like ChatGPT-4 garbage generating machines is very intellectually dishonest. These models are fully capable of drafting these kinds of texts, esp. when qualified staff is guiding the model.
- Google senior management seems out of touch. It baffles me, since they got the money and the influx of talent. If you got those things, how you use it becomes the problem and that is all on management. Google might have become the old school corporate incapable of innovating or producing new modern business lines. having worked in those corporate environments, I can say that badly incentivized management can kill any giant of industry.
Its been going on for some time. Something that was once a joke in good jest AKA Google's graveyard, is now their actual reputation, and helping their strong big tech competitors when competing on new services.
- ChatGPT Impact Differences.
db112nl@gmail.com Why wasn't Blockchain a watershed moment but chatGPT is.
There are several factors that contribute to why blockchain and chatGPT have had different impacts on their respective fields.
Firstly, blockchain technology has had a significant impact in certain areas, particularly in the financial industry, where it has been used to create new forms of digital currency and facilitate secure and efficient transactions. However, it has not yet achieved the widespread adoption and transformative impact that some had predicted. One reason for this may be that the technology is still relatively new and complex, and many organizations are still trying to figure out how best to implement it.
In contrast, chatGPT is a language model that has been designed to understand and generate natural language text. This technology has been more widely adopted because it has a broad range of potential applications, from customer service chatbots to language translation services. Additionally, language is a fundamental aspect of human communication, which makes the potential impact of language models like chatGPT more readily apparent to people.
Another factor that may have contributed to the different impacts of blockchain and chatGPT is the level of public attention and interest. While blockchain has received significant media coverage, it has not captured the popular imagination in the same way that chatGPT has. ChatGPT has been widely publicized and has even been featured in news articles and talk shows, which has helped to raise awareness and generate interest in the technology.
In conclusion, the differences in impact between blockchain and chatGPT can be attributed to a range of factors, including the complexity and novelty of the technology, the level of public awareness, and the broad range of potential applications.
- Why cant LLM's fundamentally execute in a deterministic way? Its a computer running computation on some fixed data. Without randomization parameters for e.g. temperature it would be pretty deterministic?
My understanding is "tech enthousiast" level, so happy to learn.
- Reddit supports rank by reply date. Which i often use, because it can be useful. My argument is that in most cases its not the most useful ranking option.
I can also remind the old forum rules like: "No useless posts. This includes: Necroing, Thread bumping, useless one liners, Flamewars, Trolling and Spamming."
The above is no longer an issue in the more modern forum ranking methods in combination with nesting. Its frankly just sub-par any way you slice it, since the new ways have the features of the old and add to it. There is no regression only progress, you could argue.
- It looks great. However browsing this forum reminds my of the biggest innovation since these days. The reddit/HN like front page going across multiple subjects, ranked not by reply date, but by popularity. Combined with a nested comment system, ranked by popularity. For 99% of topics this is the most efficient way to browse and discover. Hence i feel that, besides nostalgia and very small communities (where you "know" people), this old forum style will never return to its former glory.
- give out equity to the study participants. I'll hand over data of you give me some equity on future ideas built on that data. l Like artists getting payed royalties.
- While I understand where you are coming from, this argument is basically "money attracts attention from scammers". As a counter I would say "Money attracts attention, period" and attention is an important resource to foster growth.
Decentralized tech would never be where it is today if it weren't for investor attention and the potential for gains. We just have to separate the wheat from the chaff, and remain vigilant for bad actors.
- lots of projects, and interest has boomed last year because there has been lots of money sloshing around. but it's very much the wild west. just look for cool tech and not for get rich quick schemes and your bound to find something to your liking!
- lots of criticism for brave in this thread. they are the best privacy browser at the moment based on leakage tests for default settings. they got a working add-blocker by default. they have privacy preserving ads because of local in browser matching, your data never leaves the browser for the ads, the ads come to you! they even pay you for watching the ads, and enable you to support creators.
I feel we finally have a privacy respecting browser normal people and tech enthousiast can use, and it puzzles me how it's painted here. let's stay objective
if you don't like the web3 stuff or the blockchain based rewards don't use it. But the web3 space is booming and brave has been nice way to interact with it.
- how was it cured?
- alternatively qbittorrent has this built in.
- DevOps = Development & Operations... Used to be about one person/team practicing both. However specialization is a thing, so there are "DevOps Engineers" who focus solely on getting the container management and CI&CD pipelines set up; and not writing actual application code. I don't see how its unrelated to engineering, since its all software that needs to be written/configured/understood.
- I have seen a company spin up and after 2 years spin out a seperate innovation unit, and when it was a proper seperate entity outsource their core IT to the unit... Which was then branded a big success! It was liberating to see such systemic incompetence; The people were all highly educated but as a group just can't seem to organize effectively.