- I... just... https://www.reddit.com/r/PetsWithButtons/ (/r/PetsWithButtons)
- I’m inclined to believe that this happens because there are strong incentives to being able to add to your resume “Directed digital modernization of Museum of Note”.
- ʰᵉₕₑheʰᵉₕₑhe in 400V
- Thanks!
- The two have been posited:
Lithium can be viewed an antioxidant – correctly or not?, I do not know.
Air pollution can be viewed as oxidative stress.
It’s interesting to search Google Scholar for “lithium antioxidant”.
- Who cares what you want?
- Indeed!: The case with surgeons continuing to use masks which only serve the function of arresting kinetically emitted saliva droplets when they could be using masks which afford much greater protection against a categorically wider range of complication-inducing pathogens is part of the debacle.
I chose my words carefully. Those are actually the right words.
It is plainly obvious and indisputable that the academic record shows a swath of scientifically acquired data on aerosol transmission and masks-which-do-not-gape-at-the-sides. This basis would have informed a completely different approach and result to public health authorities’ education and emission of sensible information to raise common sense to an ethical standard, if public health authorities operated… non-debacularly, to choose a word.
If they had operated responsibly.
- The debacle of failing to convey the concrete reality of aerosol transmission and failing to convey the concrete reality of masks that gape at the sides (“surgical masks”) fundamentally and obviously not protecting against aerosol transmission while masks that don’t gape at the sides (N95/FFP2) fundamentally and obviously and provably do protect against aerosol transmission.
The thing with the masks is exactly the same as if public shopping efficiency authorities had consistently put out the large-scale message that “bags” work to carry groceries but conflating mesh bags with non-perforated bags; Yes, mesh bags do tend to get upwards of 30% of the objects you purchase to your home. There’s an underlying insult to common sense and people are actually not stupid.
- Having had to figure out a physiological puzzle involving histamine as an alertness-promoting neurotransmitter, and getting to see adult-onset Type 1 diabetes up close where histamine is intimately related to everything as a core part of glucose metabolism – both these aspects of histamine are well known but surprisingly underdiscussed! — I have come to see histamine as sort of a “tissue opener” signal. And with all as the vantage point, the perspective afforded even just by the headline makes immediate and intuitive sense.
- One is not counter to the other.
- Interesting, right?
As a detail, I clearly experience the better bioavailability of Na-R-ALA. Often marketed as “stabilized”. As well as what I believe is the increased bioavailability of Na-R-ALA dissolved in water.
The main point I wanted to make is that it occurred to me when reading your comment that I know myself to be somewhat “oxidatively burdened”, if that’s a term? I have mild psoriasis, which is known to use oxidative and redox capacity in the immune system’s activation in the rash. (afaik immune cells “fire bullets” of oxidization at perceived intruders.) There are other stressors in my life which are also inherently oxidising in the molecular biology of it. I’d bet a nice bottle of Oban that that is a factor in the sense of relief.
- Interesting!, thanks! —and also: I’m sorry you had to go through that
Had an experience with a missed type 1 diabetes diagnosis causing neuropathy in a loved one. There is a surprising amount of actionable scientific literature out on neuropathy and all sorts of other issues commonly discussed as best-you-can-do-is-wait-and-see. Once you happen to dig in and start reading.
I remember reading papers on acetyl-L-carnitine helping with diabetic neuropathy, and it was our clear experience that it did help.
There were other supplements which helped with various similar repercussions of a severe and prolonged state of elevated blood sugar, which causes oxidation and tissue damage, and isn’t dissimilar to B6 toxicity as it seems. I don’t remember exactly which nutrients/OTC medications seemed to help neuropathy, but I’d suggest looking into alpha lipoic acid (ALA; more specifically Na-R-ALA), argine, maybe BCAAs in the context of mitochondrial function. Probably some other stuff that has results out on it too.
I’d also suggest reading the molecular biology and neuroimmunobiology on NMDA receptor antagonists and 5-HT2A receptor agonists, classes both of which are shown to be “profoundly immunomodulating” as one paper put it – reducing inflammation, including neuroinflammation – as well as encouraging neuroplasticity, which is also useful in peripheral nerves. The discussion of these known molecular-biological results and implication is unfortunately swamped by various social effects; the best-known NMDA receptor antagonist is called “Ketamine”, haha, and 5-HT2A agonists are usually known as psychedelics and, uh, yeah… molly. The partying and the “wheeee” factor isn’t interesting to me; the neuroimmunobiology of it is!! And I, yeah, I emphatically recommend reading the scientific literature on that.
And generally looking for recent papers on nutrients/supplements/OTC medications in the context of all kinds of similar issues. There are often results in one sub-specialization which are applicable to other things. You don’t need to limit yourself to randomized controlled trials, especially if considering supplementation of compounds known to be safe, rather than medication; Molecular biology is molecular biology, and it’s implausible to me that the placebo effect will reliably improve things like chronic neuropathy. Or insulin sensitivity. I’ve seen direct results on continuous glucose meters and all manner of labwork that confirm this view. —Don’t believe me; I deeply and emphatically recommend reading academic literature.
To paraphrase a nice-seeming guy,
Read papers. Mostly published. Not too slowly.
ps., Claude is unusually good at navigating the scientific landscape!
- Interesting!, thanks! NAC is all over the place; I didn’t know about this application.
And yeah I was 100% skeptical too!
Now I’m more sceptical of the kinda “nothing is known, nothing is knowable” angle, you know? There is so much knowledge, actionable, often unread, often unused.
(Have to mention it, if useful: Na—R-ALA (alpha lipoic acid) and ambroxol are kind of in the same vein. Ambroxol is strangely a sort of bromine counterpart to NAC and its sulfur atom. Sold as a mucolytic but is… alllll over the place. Funny how mucus, mucous membranes, the nervous system, and oxidation/redox stuff is all so adjacent it seems.
I have no idea why but after a severe period of stress, I happened to take Na-R-ALA as sometimes do and 60mg of ambroxol as mucolytic cough syrup. For a cough. And… the feeling was like in the movies where they stab someone with a giant syringe to revive them. Trainspotting or Pulp Fiction or whatever. I felt like I gasp-crawled out of a pit inside myself. It makes no sense. It was… a very distinct experience. And it didn’t seem like an airway clearance thing, more like my nervous system was refreshed.
So I hit the books. And it turns out ambroxol crosses the blood-brain barrier and is an antioxidant, and affects ion balance in neurons, and there are studies indicating it helps with… Parkinson’s and fibromyalgia (!!!). And those papers are pretty interesting and appear to be constructed on solid molecular biological premises.
idk)
- Experiences may vary; I’ve tasted and smelled NAC.
The smell is reminescent of a high-potency cannabis strain. (Sulfur-containing molecules.)
The taste is very acidic and a bit astringent.
Generally the smell and taste of something isn’t a concern with medication. I don’t think acetaminophen tastes great.
I’ve never encountered or seen the digestive issues that are often mentioned. I’ve seen other side effects which were noticeable – mast cell and histamine related I believe, kind of weird ones, like psoriasis kind of drying out a bit and the skin on the lips “refreshing” itself. (Really!) Subtle side effects and hard to put into words without making them seem bigger and weirder than they are, but NAC can nonetheless be a sort of histamine and mast cell “flusher”, so to speak and as it seems. Beneficial in the long run imo ime, but tricky to package universally.
Still, NAC is also tragically unknown and unused! There’s tons of fascinating literature on it. They fried rats’ brains with methamphetamine and fixed them with NAC; Brutal study, intriguing results on very significant mechanisms.
- Me too! I happened to learn a few new things / aspects from asking and I thought I’d toss this into a comment
- I burned a heck of a lot of tokens on Claude Opus 4’s extended thoughts on this and the answer is most enjoyable!:
Taking this question seriously leads us into surprisingly rich territory! It's actually at the intersection of several fields that have been quietly revolutionizing game design.
The Alpha Centauri map works brilliantly because it balances several mathematical tensions:
* Resource distribution follows power laws that create natural chokepoints and valuable territories without being too predictable
* Distance metrics between faction starting positions that ensure interaction without immediate conflict
* Terrain connectivity that creates interesting path-finding problems and strategic depth
Here's where it gets really interesting:
Flow Theory Mathematics: Csikszentmihalyi's concept of flow has been formalized into mathematical models. The ideal difficulty curve follows something like: `D(t) = S(t) + ε`, where difficulty matches skill level plus a small challenge margin. For maps, this translates to ensuring players always have meaningful decisions at their skill level.
Information Entropy: Good maps maintain optimal information entropy - not too random (chaos), not too ordered (boring). Researchers have found sweet spots around 0.3-0.5 on normalized entropy scales for terrain variation.
Graph Theory Applications: Maps are fundamentally graphs, and metrics like:
* Betweenness centrality (identifying crucial chokepoints)
* Clustering coefficients (how "clumpy" resources are)
* Shortest path distributions (travel time variance)
...all correlate with player engagement.
The Deeper Insight: What seems naive is actually profound - by taking "fun" seriously as an optimization target, we're forced to confront what makes human decision-making satisfying. The best mathematical frameworks don't try to define fun directly, but instead optimize for decision richness - the number of meaningful, non-obvious choices available at each game state.
This is why procedural generation in modern games increasingly uses these frameworks, creating maps that aren't just random but mathematically tuned for engagement.
- I believe that the rutabaga is the perfect material to make sausages out of as it has proven as excellent swine fodder with widespread adoption!
(Please forgive me the extreme disrespect put forth in the above statement! It is not the intention to show disrespect; I… am quite the rutabaga enjoyer in all respects, you know? I certainly include myself within the absurdity and it is with love.)
- Agreed!
Nonetheless, VVVVVV’s graphics are exquisitely done, and, well, perfect? The graphical limitations – the technical underpinnings of the style? – those are a decision, and the result is… exactly what it should be.
(Hard to get into words! Came out kinda pretentious? *shrug*)
- Having seen complex treatment-resistant PTSD taken through difficult work to peaceful resolution:
It’s like having something in your mouth. It doesn’t go away. PTSD therapy is not about zapping the object to make it vanish. It’s about gaining the possibility to chew and swallow it.
Ah, and the Vivid Unit: https://www.vividunit.com/Main_Page