It becomes worthwhile if its actually cheaper (probably significantly cheaper given R&D and risk), or if you're processing data which originates in space and the data transfer or latency is an issue
You can set up plant manufacturing chips in shipping containers and sending them to wherever energy/land is cheapest and regulation most suitable, without having to seek the FCCs approval to get launch approved and your data back...
people use aws despite it being 2x-10x the cost of self hosting. cost isnt everything.
I do wonder, at what factor of orbital to terrestrial cost factor it becomes worthwhile.
The greater the terrestrial lead time, red tape, permitting, regulations on Earth, the higher the orbital-to-terrestrial factor that's acceptable.
A lights-out automated production line pumping out GPU satellites into a daily Starship launch feels "cleaner" from an end-to-end automation perspective vs years long land acquisition, planning and environment approvals, construction.
More expensive, for sure, but feels way more copy-paste the factory, "linearly scalable" than physical construction.