I remember a radio host in the 90's remarking about how ironic it was that three of the biggest movie directors at the time were: Opie (Ron Howard), Laverne (Penny Marshall) and MeatHead (Rob Reiner).

Indeed. I grew up watching AitF, and I remember being totally floored when I realized he directed “When Harry Met Sally.”

Really sad end to a great career and as far as I could tell, a decent human being.