What do you use in Windows? It's probably easier starting there and then working out what you can do about it.
Games work great in Proton. Valve has gone all-in on Linux and I suspect before terribly long we'll see more stuff that's SteamOS native, with a compatibility layer for the people who are still using Windows.
I would suspect now that most people either play games which will mostly work okay from Steam, or use stuff that just works in a browser (and I'm kind of lumping Electron apps in with that). Then there are things that are never going to work all that well in Wine or have a native Linux port but which might be worth looking into something else for, like switching from Premiere to Resolve for video editing.
Games work great in Proton. Valve has gone all-in on Linux and I suspect before terribly long we'll see more stuff that's SteamOS native, with a compatibility layer for the people who are still using Windows.
I would suspect now that most people either play games which will mostly work okay from Steam, or use stuff that just works in a browser (and I'm kind of lumping Electron apps in with that). Then there are things that are never going to work all that well in Wine or have a native Linux port but which might be worth looking into something else for, like switching from Premiere to Resolve for video editing.