Typst has 50 years of accumulated TeX experiences to learn from, and fit everything people actually want to use into a 45M binary, and maybe you'll download a few dozen K of package scripts.
I have used it for much more than academic publishing (book, brochure, and even card layout) and it's hands-down the best tool ever made for producing documents of any imaginable kind. Procedurally producing layouts from first-class JSON and CSV support is bliss.
I find myself switching between cli and web app a little more; the web app seems nice to experiment, share experiments especially when you need to demonstrate an issue when getting support, and has good enough git(hub) integration.
I would like Typst to support bounties, because I would throw a bit more towards HTML support.
The example in this link of character-level justification is incredibly nice (enough to get me to try Typst), but it's not clear at least from this link whether they're actively working on microtypography.
I love, and hate, LaTeX and the idea of a LaTeX successor / alternative is incredibly appealing.
And the fact that they are aware that microtypography IS important and that they are working on it is a huge huge plus.