What's old is new again. The original 68000 processor only had a 24-bit physical address bus, so the MacOS used the upper 8 bits for tag information, and didn't even need to clear it when accessing. Once they started using CPUs and more RAM that needed these upper bits, they had to make "32-bit clean" versions of programs.

I wonder whether you could use the MMU to ignore these upper bits, by mapping each combination of bits to the same address as with them clear.