Vuescan is terrible. SilverFast has better defaults. But nothing beats the orig Nikon scan software when using ICE. It does a great job of removing dust, fingerprints etc Even when you zoom in. VS what iSRD does in SilverFast, which if you zoom in and compare the 2. iSRD kinda smooches/blurs the infrared defects whereas Nikon Scan clones the surrounding parts, which usually looks very good when zooming in.

Both Silverfast and Nikon Scan methods look great when zoomed out. I never tried Vuescan's infrared option. I just felt the positive colors it produced looks wrong/"dead".