The article made it up. It's pure speculation. Hundreds of thousands of people take pepper+curcumin supplements and are totally fine.
What's likely the culprit here is an idiosyncratic immune response, or a heavy metal contaminated supplement. Of course, that's also speculative. Could be something she ate; could be that she didn't disclose a drinking problem.
The article reads like it has an axe to grind, tbh. "Oh no an unregulated racket!"
“Importantly, means of increasing the bioavailability of curcumin were developed using piperine (black pepper) or lipid nanoparticle delivery methods to increase absorption. These high bioavailability forms of purified curcumin were subsequently linked to several cases of liver injury and mentioned as a possible cause of outbreaks of acute hepatitis with jaundice in Italy.”
https://www.ncbi.nlm.nih.gov/books/NBK548561/
So no, the article didn’t make it up. In fact, you made up the claim that they made it up. Seems like you are the one with an axe to grind.
See, e.g.: https://i.ibb.co/Qvbdjqf7/amazon-curcumin.png
My impression as an author with books on Amazon is that you get one review or rating for every 20-30 purchases, and there are two products with "200k people have purchased multiple times."
And that's to say nothing of people who have bought such products via other sources, like Wal-Mart, etc.
All that, and you have "several" cases? That's not a lot. You need much stronger evidence to support any assertion that the nature of the product is harmful. (As opposed to contamination or chance effects.) If anything, I'd say that purchase and utilization statistics support the notion that the product is not harmful.
Although it seems this needs more research, I'd be wary dismissing it out of hand just because people haven't been having an acute reaction.
When I checked the turmeric supplement I use. Which I buy in a reputable health food, and supplement chain in Norway. It is 40mg of turmeric, which according to the article is well under the acceptable daily dose. As far as I understand Norway follows the EU directives on this, but has some additional strictures as well. I wouldn't expect the difference to be this stark though.
Btw. the reason I use turmeric supplements is that I have a tendency to get persistent inflammation, and for me, the supplements seems to help with that. But if I didn't have this problem, I would not take it, and also, it isn't given that it works for you, even if it does for me.
It's worse in the US because the FDA effectively "washes its hands" of anything deemed a "supplement". In general, the precautionary principle is difficult to find in America outside of FDA-approved procedures, medical devices, and medications. Food and supplements are desperately under-regulated.
The "natural" supplement industry lobbied for, and obtained, a law that makes them unregulatable.
https://en.wikipedia.org/wiki/Dietary_Supplement_Health_and_... ("Dietary Supplement Health and Education Act of 1994")
> "The act was intended to exempt the dietary and herbal supplement industry from most FDA drug regulations, allowing them to be sold and marketed without scientific backing for their health and medical claims.[3]"
one, it's extremely likely that the article is incomplete and lack critical info like a presence of lead, or genetic predisposition.
Two: 10g is crazy. That's how you get kidney stones. Put so curcuma and black pepper in your meals. In EU, supplements (and recently, tea) are tested for heavy metal and plastic, and to see if the ingredient list is correct, but their effectiveness is not.
I've seen a bunch of pills that look basically like those, and the most they have held is around 1000mg.
Here are some pills that look just like the ones in the article's picture:
https://www.amazon.com/NatureWise-Curcumin-Curcuminoids-BioP...
They are 2250 + 500 = 2750mg in a serving size of 3 pills. So each pill is slightly less than 1000mg.
Edit: in europe
I heard it is good, not trusting generic "healthy wonder medicines" in general.
I think I'd rather mine in Chicken Korma than some pill.
See Article 6 and on: https://eur-lex.europa.eu/eli/reg/2006/1924/oj/eng
https://peixeverde.pt/wp-content/uploads/2023/01/curcumega-8...
Pretty sure that is a mg, not an μg
Composition: Per capsule:
Turmeric (equivalence) - 10 000 mg; Turmeric (containing at least 95% curcumin) - 350 mg; Turmeric (exact 5:1) - 150 mg; Black Pepper - 5 mg; Vitamin C - 80 mg (100% VRN ); Zinc - 10 mg (100% VRN )
I looked on my table toward the bottle of turmeric my parents gifted me recently, saying they heard it was good and bought on a famous "health" store.
Bottle is: turmeric + pepper "designed for max absorption" and dose is 10000mg.