While the space wasted by GPT and partitions and by the arbitrary alignment rules used by various formatting tools is not great, I do not see any reason why it should exist. The space wasted now with GPT and UEFI is several orders of magnitude greater than it was with traditional partition tables, so eliminating it has become more attractive.
Such SSDs and HDDs are not bootable, but for me this is a desirable feature, not a bug. I boot my computers either from Ethernet (e.g. most of my servers) or from a removable USB memory.
The SSDs and HDDs with a whole-disk file system are also wholly encrypted. As in a proper encryption implementation, there is complete separation between the encrypted data and the encryption key. The encrypted disks or their hosting computers do not contain any information about decryption, unlike in many systems of disk encryption. The encrypted decryption keys can be found only on external or remote boot media, which are not normally associated with the hosting computers.
I wouldn't recommend that. It makes the disk appear to be empty to many tools (and possibly some operating systems), which could lead to data loss. That's the reason GPT has the protective MBR: it makes the disk appear to be full to legacy tools which don't understand the GPT format.
Windows frequently overwrites any bootable Linux drive, so it might have even less restraints with an apparently empty drive that does not have GPT structure.
Because of the risk of Windows messing with them, I also do not insert any of my bootable USB memories in a live Windows computer, even when they have GPT structure. For data interchange with Windows, I use only clean and non-bootable exFAT formatted USB memories.
I am not the OP and I do not do this. However...
Yes, the disk space used is a rounding error and one far right of the decimal point.
But there is extra space used in the human brain that sets this up.
Instead of `/dev/sda1` it's `/dev/sda`. Instead of `/dev/nvme0l0p1` or whatever (I own almost no NVMe kit) it's `/dev/nvme0l0`. And so on.
This could be helpful; I can certainly imagine it simplifying things somewhat.