Personally, my grandmother was forced to switch from left handed to right handed! In those days (early 1900s) the forced switch often came under threat of violence. Yes, they beat children to make them write "right". So this is a sensitive topic for a lot of people!
[1] https://en.wikipedia.org/wiki/Bias_against_left-handed_peopl... [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758284/
Swing a bat/club? Right-handed. Throw a ball? Right-handed. Use a computer mouse? Right-handed. Shoot a rifle? Right-handed. Write a note? Left-handed. Paint a picture? Left-handed.
I would swap L/R button functions on the Sun4 3-button optical mouse and set it to the left of the keyboard. This is a comfortable and natural position, especially considering the placement of the numpad.
Very soon, the word was out in the office, and NOBODY attempted to borrow my workstation!