> In the study, E coli carrying a resistance gene, called MCR-1, were exposed to AMPs known to play important roles in innate immunity in chickens, pigs, and humans.
If the same kinds of AMPs appear across mammals and birds, breaking the monoculture (by e.g. raising animals of different breeds and species etc) but still using this class of antibiotics would still seem likely to cause the immune resistance problem. I'm not advocating for the monoculture-based practices, but I don't see how it's related to this specific mechanism.
darkerside
I think the connection to monoculture is that specific pathogens could decimate homogenous populations (see Irish potato famine), making widespread antibiotic use necessary in a much more preventative way
If the same kinds of AMPs appear across mammals and birds, breaking the monoculture (by e.g. raising animals of different breeds and species etc) but still using this class of antibiotics would still seem likely to cause the immune resistance problem. I'm not advocating for the monoculture-based practices, but I don't see how it's related to this specific mechanism.