> In a paper published today in Nature, researchers report refashioning Photorhabdus’s syringe—called a contractile injection system—so that it can attach to human cells and inject large proteins into them. The work could provide a way to deliver various therapeutic proteins into any type of cell, including proteins that can “edit” the cell’s DNA. “It’s a very interesting approach,” says Mark Kay, a gene therapy researcher at Stanford University who was not involved in the study. “Where I think it could be very useful is when you want to express proteins that can do genome editing” to correct or knock out a gene that is mutated in a genetic disorder, he says.
> The nano injector could provide a critical tool for scientists interested in tweaking genes. “Delivery is probably the biggest unsolved problem for gene editing,” says study investigator Feng Zhang, a molecular biologist at the McGovern Institute for Brain Research at the Massachusetts Institute of Technology and the Broad Institute of M.I.T. and Harvard. Zhang is known for his work developing the gene editing system CRISPR-Cas9. Existing technology can insert the editing machinery “into a few tissues, blood and liver and the eye, but we don’t have a good way to get to anywhere else,” such as the brain, heart, lung or kidney, Zhang says. The syringe technology also holds promise for treating cancer because it can be engineered to attach to receptors on certain cancer cells.
> In a paper published today in Nature, researchers report refashioning Photorhabdus’s syringe—called a contractile injection system—so that it can attach to human cells and inject large proteins into them. The work could provide a way to deliver various therapeutic proteins into any type of cell, including proteins that can “edit” the cell’s DNA. “It’s a very interesting approach,” says Mark Kay, a gene therapy researcher at Stanford University who was not involved in the study. “Where I think it could be very useful is when you want to express proteins that can do genome editing” to correct or knock out a gene that is mutated in a genetic disorder, he says.
> The nano injector could provide a critical tool for scientists interested in tweaking genes. “Delivery is probably the biggest unsolved problem for gene editing,” says study investigator Feng Zhang, a molecular biologist at the McGovern Institute for Brain Research at the Massachusetts Institute of Technology and the Broad Institute of M.I.T. and Harvard. Zhang is known for his work developing the gene editing system CRISPR-Cas9. Existing technology can insert the editing machinery “into a few tissues, blood and liver and the eye, but we don’t have a good way to get to anywhere else,” such as the brain, heart, lung or kidney, Zhang says. The syringe technology also holds promise for treating cancer because it can be engineered to attach to receptors on certain cancer cells.