I do not think is a bad idea to be multi-region from start. For the most part Azure has at least two regions in each country (Germany North/West Central, UK South/West, Sweden South/Central, Norway East / West, UAE North / Central, France Central / South etc....)So if stuff happens being able to bring up your service in a different region in the same country could be helpful. I do not know specifics but it seems to me that having an abstraction layer on top of the region is not that hard to do (most of Azure services are supported in all regions). OF course, is a lot easier if done at the outset. Being forced to do it quickly and with little notice is no fun at all....