It probably matters for a few of the slower ones, like Java, Go, or Dart. It's also going to matter on what platform. eg, Java may have better FFI on x86 than on ARM. Or similarly Dart's FFI may better on ARM than on x86, particularly given Flutter is the primary user these days.

And then to make it even more complicated it's also going to potentially depend on the GC being used. For example for Java's JNI it's actually the bookkeeping for the GC that takes the most time in that FFI transition (can't pause the thread to mark the stack for a concurrent GC when it's executing random C code, after all). Which is going to potentially depend on what the specific GC being used requires.