Exactly, this stuff needs to be monitored either intensely for 24 hours (or maybe even longer), or periodically for longer periods of time (days, weeks, months). What they did doesn't really give us useful data other than "directionally this is an area for more investigation."
Maybe I'm stretching this, but I want more calorie expenditure while I'm sleeping and having the highest amount of somatotropin in my body so it can mobilize proteins and facilitate healing.
Your compliance point is salient. I can recommend every single therapy in the book, but getting a patient to take a drug let alone at the correct time and correct dosage to maintain therapeutic index, is an art.