All estimates point to the future where there will be multiple mega-airports with more than 100 million passengers in Asia.
Large Aircraft are great economically, as long as they can be kept full. But, this tends to be limited as only a tiny fraction of routes can support such beasts.
IATA estimates point to several new 100m airports in 10-15 years.
Now, sure with continued growth eventually you need larger aircraft. But, while demand might pick up they have plenty of time to design a successor especially as they can simply look at 747-800 sales numbers.
What has actually happened is that hubs became more numerous and smaller. A major airline might have 6 hubs instead of 2. And most long distance trips are done with 2 legs instead of 3.
Remember, mini hubs are near major destinations so people are very likely to be starting or stopping at one, Combined with different airlines 1 hops vs 2 or 3 is common, but more so 2 hops vs 3 or 4.
Remeber, a hub and spoke trip means 2-3x the landings and relies on extremely congested airports. So, point to point has significantly shifted what gets congested. Things may look different in 25 years, but that’s a long time.