The Shuffle supports loading multiple playlists, which you can set in any order you like. You can also choose "shuffle" mode (in other words, you're not stuck with "shuffle" playback on the iPod Shuffle).
Assuming you mean Toyota 4Runner: As long as your 4Runner has an aux port, you should be able to connect the Shuffle with a male-to-male audio extension cable.
I've considered buying a Shuffle now as I don't really care what order the music is in, but I don't know if the Forerunner I have will connect to it (everything I've read in my cursory search specifically says "phone").